Endocrine Abstracts

Polycystic Ovary Syndrome (PCOS), the most common endocrinopathy affecting reproductive-aged women, is characterized by oligo-/anovulation, hyperandrogenism and polycystic ovaries. In PCOS women with anovulatory infertility, the accepted first-line treatment is clomiphene citrate (CC). For patients resistant to CC, laparoscopic ovarian drilling (LOD) is recommended as a second-line therapy. Whilst very effective, LOD is an invasive technique requiring general anaesthesia and a...

Polycystic Ovary Syndrome (PCOS), the most common endocrinopathy of reproductive-age women, was initially defined by the association of anovulation and clinical and/or biochemical hyperandrogenism (1990 NIH). Since Rotterdam Consensus Conference in 2003, its diagnosis requires the presence of at least two of the following features: oligo-/anovulation, hyperandrogenism and polycystic ovaries on ultrasound. However, since its introduction, this definition was strongly challenged...

Introduction: Polycystic Ovary Syndrome (PCOS) is a very common endocrinopathy affecting 6 to 13% of women of reproductive age and one of the leading causes of female poor fertility. It was initially defined by the association of anovulation and clinical and/or biochemical hyperandrogenism (1990 National Institutes of Health-sponsored conference). Since Rotterdam ESHRE/ASRM Consensus Conference in 2003, polycystic ovaries morphology on ultrasound (ECHO condition) was added as ...

Diet, and especially metabolic dysregulation such as obesity can influence the ovarian activity. Adipose tissue plays an important role since it is known to be one of the most important endocrine organs producing hundreds of cytokines, such as adiponectin. Our team has observed that adiponectin modulated steroid secretion by the ovarian granulosa cells and its concentration in the follicular fluid was influenced by the metabolic status. Recently, a small adiponectin mimetic sy...

Water and electrolyte balance regulation plays a key role in essential hypertension pathogenesis. Indeed, alterations in kidney ability to excrete sodium and water in relation to intake have been proposed as a basic process of hypertension development. Vasopressin (AVP) acts through V2 receptors on the basolateral membrane of collecting duct principal cells to trigger the phosphorylation of Aquaporin 2 (AQP2) which moves from the cytoplasm to the apical membrane, making the ce...

Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants derived from the incomplete combustion of organic materials. In urban and industrial areas, level of pollution with these compounds is high, which leads to numerous negative health effects. Some literature data indicate the involvement of PAHs in the development of obesity, however, there is no data showing the distribution patterns of PAHs in human adipose tissue (AT) and their impact on the process o...